Our exciting advances in using PEGylation as an effective tool to stabilize fluorescent proteins in solid-state down-converters integrated into bio-hybrid light-emitting diodes is out in Adv. Funct. Mater.
This strategy has already been shown to be effective in reducing denaturation and immunogenicity in therapeutic proteins, as well as in bioimaging and drug delivery. Our photoluminescence, thermocycling, and electrochemical impedance spectroscopy data show that PEGylation is also successful in reducing nonreversible thermal denaturation and aggregation as well as photo-induced oxidation and H-transfer deactivation of the chromophore, since oxygen diffusivity and H-reorganization across the protein skeleton are slowed down by strong H-bonding/hydrophobic FP-mPEG interactions.
Enjoy the paper: https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202412921